The results dated the specimens to involving 3780 and 3660 BCE. Alkaloid extraction yielded about 2% with the alkaloids which includes mescaline in the two samples. This indicates that indigenous North Americans have been very likely to have made use of peyote because a minimum of 5-and-a-50 % thousand yrs https://peyotecactusseeds.com/product/peyote-button-seeds/