There exists a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to minimize afferent discomfort transmission and develop analgesia. Hence, drugs like clonidine that focus on alpha-two receptors can influence the transmission of discomfort. : connected to, served by, or https://greatj516mtn0.life-wiki.com/user