Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts within the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions,... https://franzv752pwe9.evawiki.com/user