This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the medical response to doxycycline ought to be monitored carefully. Phenytoin, sodium valproate, valproic acid: The impact of barbiturates to the metabolism of phenytoin seems to get variable. https://robertq134fbu9.nico-wiki.com/user